High-resolution copies of images used in this story are linked from
the thumbnails below. Please credit the images as indicated.
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| Dr. Robert Richmond extracts breast cell tissue from one of two liquid nitrogen
dewars. Links to 1378x1924-pixel, 926KB JPG.
Credit: Dennis Olive, NASA/Marshall Space Flight Center |
Two of several Bioreactors used by Dr. Richmond in his research. Links to
1966x1378-pixel, 764KB JPG. Credit: Dennis
Olive, NASA/Marshall Space Flight Center |
Breast tissue specimens in traditional sample dishes. Links to 1595x1917-pixel, 1.2MB JPG. Credit: Dennis Olive,
NASA/Marshall Space Flight Center |
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| Dr. Harry Mahtani anlyzes the gas content of nutrient media in the Bioreactors.
Links to 1561x1200-pixel, 702KB JPG. Credit:
Dennis Olive, NASA/Marshall Space Flight Center |
Time-lapse exposure of Bioreactor rotation. Links to 2000x1507-pixel,
1.1MB JPG. Credit: Dennis Olive, NASA/Marshall Space Flight Center |
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Human primary breast tumor cells after 56 days of culture in a NASA
Bioreactor.
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| A cross-section of a construct, grown from surgical specimens
of breast cancer, stained for microscopic examination, reveals areas of
tumor cells dispersed throughout the non-epithelial cell background. The
arrow denotes the foci of breast cancer cells. Links to 1174x766-pixel,
518KB JPG. Credit: Dr. Jeanne Becker, University of South Florida. |
Higher magnification of view at left. The arrow points to
bead surface indicating breast cancer cells (as noted by the staining of
tumor cell intermediate filaments). Links to 1179x771-pixel,
405KB JPG. Credit: Dr. Jeanne Becker, University of South Florida. |
Human primary breast tumor cells after 49 days of growth in a NASA Bioreactor.
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| Tumor cells aggregate on microcarrier beads (indicated by
arrow). Links to 1171x796-pixel, 271KB JPG.
Credit: Dr. Jeanne Becker, University of South Florida. |
Higher magnification of view at left, illustrating breast
cancer cells with intercellular boundaries on bead surface and aggregates
of cells achieving 3-dimensional growth outward from bead. Links to 1165x785-pixel, 339KB JPG. Credit: Dr. Jeanne
Becker, University of South Florida. |
Isolation of human mammary epithelial cells (HMEC) from
breast cancer susceptible tissue
(These are enlarged images from the first composite set on the main story)
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B: Outgrowth of cells from duct element in upper right corner cultured
in a standard dish; most cells spontaneously die during early cell divisions,
but a few will establish long-term growth.
Links to 1441x1101-pixel, 637KB JPG. Credit:
Dr. Robert Richmond, NASA/Marshall Space Flight Center. |
C: Isolate of long-term growth HMEC from outgrowth of duct element;
cells shown soon after isolation and in early full-cell contact growth in
culture in a dish.. Links to 1476x1141-pixel,
637KB JPG. Credit: Dr. Robert Richmond, NASA/Marshall Space Flight Center. |
D: Same long-term growth HMEC, but after 3 weeks in late full-cell
contact growth in a continuous culture in a dish. Note attempts to reform
duct elements, but this time in two dimensions in a dish rather than in
three dimensions in tissue. Links to 1800x1184-pixel,
748KB JPG. Credit: Dr. Robert Richmond, NASA/Marshall Space Flight Center. |
Note: Image A appears at full resolution in the linked composite on the
first page.
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